Journal article

Multiday cycles of heart rate modulate seizure likelihood at daily, weekly and monthly timescales: An observational cohort study

Philippa Karoly, Rachel Stirling, Dean Freestone, Ewan Nurse, Brendan Doyle, Amy Halliday, Andrew Neal, Wenjuan Xiong, Tatiana Kameneva, Nicholas Gregg, Benjamin Brinkmann, Mark Richardson, Sonya Dumanis, Andre La Gerche, David Grayden, Wendyl D’Souza, Mark Cook

Published : 2020


Circadian and multiday rhythms are found across many biological systems, including cardiology, endocrinology, neurology and immunology. In people with epilepsy, epileptic brain activity and seizure occurrence have been found to follow circadian, weekly and monthly rhythms. Understanding the relationship between these cycles of brain excitability and other physiological phenomena can provide new insight into the causes of multiday cycles. The brain-heart link is highly relevant for epilepsy, with implications for seizure prediction, therapy (i.e. vagal nerve stimulation) and mortality (i.e. sudden unexpected death in epilepsy). We report the results from a non-interventional, observational co..

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