Epigenetic mechanisms involved in intrauterine growth restriction and aberrant kidney development and function

TNA Doan; JF Briffa; AL Phillips; SY Leemaqz; RA Burton; T Romano; ME Wlodek; T Bianco-Miotto

Journal article

Epigenetic mechanisms involved in intrauterine growth restriction and aberrant kidney development and function

TNA Doan, JF Briffa, AL Phillips, SY Leemaqz, RA Burton, T Romano, ME Wlodek, T Bianco-Miotto

Journal of Developmental Origins of Health and Disease | CAMBRIDGE UNIV PRESS | Published : 2021

DOI: 10.1017/S2040174420001257

Abstract

Intrauterine growth restriction (IUGR) due to uteroplacental insufficiency results in a placenta that is unable to provide adequate nutrients and oxygen to the fetus. These growth-restricted babies have an increased risk of hypertension and chronic kidney disease later in life. In rats, both male and female growth-restricted offspring have nephron deficits but only males develop kidney dysfunction and high blood pressure. In addition, there is transgenerational transmission of nephron deficits and hypertension risk. Therefore, epigenetic mechanisms may explain the sex-specific programming and multigenerational transmission of IUGR-related phenotypes. Expression of DNA methyltransferases (Dnm..

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University of Melbourne Researchers

Dr Jessica Briffa Author

Prof Mary Wlodek Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by Heart Foundation

Funding Acknowledgements

This research was supported by the National Health and Medical Research Council (NHMRC) of Australia (M.E.W.; 1045602), the Heart Foundation (M.E.W.; G 11M 5785), a La Trobe University Faculty of Health Sciences Research Grant Award (T.R.), and a Robinson Research Institute (RRI) Seed Grant (T.B-M, M.E.W. and J.F.B.) and supported by the School of Agriculture, Food and Wine, University of Adelaide.