Journal article

"Benign" temporal lobe epilepsy with hippocampal sclerosis: A forgotten entity?

Emmanuel Cheng Seng Leong, Udaya Seneviratne

EPILEPSY & BEHAVIOR REPORTS | ELSEVIER SCIENCE INC | Published : 2020

Abstract

Mesial temporal lobe epilepsy, a well-characterized epilepsy syndrome, is most commonly accompanied by the pathological feature of hippocampal sclerosis. Patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) typically present in childhood to early adolescence. We describe a cohort of patients who presented with their first epileptic seizure in late adulthood with atypical features. We characterized five patients with late-onset MTLE-HS by describing their demographics, electroclinical features, imaging, autoantibody status, and response to antiseizure medication (ASM) therapy. All five patients had their first seizure after the age of 50 with no history of initial ..

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