Journal article

General psychopathology links burden of recent life events and psychotic symptoms in a network approach

Linda T Betz, Nora Penzel, Lana Kambeitz-Ilankovic, Marlene Rosen, Katharine Chisholm, Alexandra Stainton, Theresa K Haidl, Julian Wenzel, Alessandro Bertolino, Stefan Borgwardt, Paolo Brambilla, Rebekka Lencer, Eva Meisenzahl, Stephan Ruhrmann, Raimo KR Salokangas, Frauke Schultze-Lutter, Stephen J Wood, Rachel Upthegrove, Nikolaos Koutsouleris, Joseph Kambeitz

npj Schizophrenia | NATURE RESEARCH | Published : 2020

Abstract

Recent life events have been implicated in the onset and progression of psychosis. However, psychological processes that account for the association are yet to be fully understood. Using a network approach, we aimed to identify pathways linking recent life events and symptoms observed in psychosis. Based on previous literature, we hypothesized that general symptoms would mediate between recent life events and psychotic symptoms. We analyzed baseline data of patients at clinical high risk for psychosis and with recent-onset psychosis (n = 547) from the Personalised Prognostic Tools for Early Psychosis Management (PRONIA) study. In a network analysis, we modeled links between the burden of rec..

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