Journal article

Morphometric Changes to Corneal Dendritic Cells in Individuals With Mild Cognitive Impairment

Cirous Dehghani, Shaun Frost, Rajiv Jayasena, Christopher Fowler, Colin L Masters, Yogesan Kanagasingam, Haihan Jiao, Jeremiah KH Lim, Holly R Chinnery, Laura E Downie

Frontiers in Neuroscience | FRONTIERS MEDIA SA | Published : 2020

Abstract

Purpose: There has been increasing interest in identifying non-invasive, imaging biomarkers for neurodegenerative disorders of the central nervous system (CNS). The aim of this proof-of-concept study was to investigate whether corneal sensory nerve and dendritic cell (DC) parameters, captured using in vivo confocal microscopy (IVCM), are altered in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Methods: Fifteen participants were recruited from the Australian Imaging Biomarkers and Lifestyle (AIBL) study in Melbourne, VIC, Australia. The cohort consisted of cognitively normal (CN) individuals (n = 5), and those with MCI (n = 5) and AD (n = 5). Participants unde..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Dementia Research Fellowship


Funding Acknowledgements

This study did not receive any specific funding support. SF was supported by a National Health and Medical Research Council (NHMRC) Dementia Research Fellowship (GNT1099457).