Spatiotemporal Patterns of High-Frequency Activity (80-170 Hz) in Long-Term Intracranial EEG
Zhuying Chen, David B Grayden, Anthony N Burkitt, Udaya Seneviratne, Wendyl J D'Souza, Chris French, Philippa J Karoly, Katrina Dell, Kent Leyde, Mark J Cook, Matias I Maturana
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021
OBJECTIVE: To determine the utility of high-frequency activity (HFA) and epileptiform spikes as biomarkers for epilepsy, we examined the variability in their rates and locations using long-term ambulatory intracranial EEG (iEEG) recordings. METHODS: This study used continuous iEEG recordings obtained over an average of 1.4 years from 15 patients with drug-resistant focal epilepsy. HFA was defined as 80- to 170-Hz events with amplitudes clearly larger than the background, which was automatically detected with a custom algorithm. The automatically detected HFA was compared with visually annotated high-frequency oscillations (HFOs). The variations of HFA rates were compared with spikes and seiz..View full abstract
Awarded by China Scholarship Council
Awarded by Australian National Health and Medical Research Council
Supported by China Scholarship Council (201709120011) and an Australian National Health and Medical Research Council Project Grant (1130468).