Effects of the food additive monosodium glutamate on cisplatin-induced gastrointestinal dysmotility and peripheral neuropathy in the rat
Yolanda Lopez-Tofino, Gema Vera, Laura Lopez-Gomez, Rocio Giron, Kulmira Nurgali, Jose A Uranga, Raquel Abalo
NEUROGASTROENTEROLOGY AND MOTILITY | WILEY | Published : 2020
BACKGROUND: Cisplatin is an antineoplastic drug known to produce intense vomiting, gastric dysmotility, and peripheral neuropathy. Monosodium glutamate (MSG) is a flavor enhancer with prokinetic properties potentially useful for cancer patients under chemotherapy. Our aim was to test whether MSG may improve gastrointestinal motor dysfunction and other adverse effects induced by repeated cisplatin in rats. METHODS: Male Wistar rats were exposed or not to MSG (4 g L-1 ) in drinking water from week 0 to 1 week after treatment. On the first day of weeks 1-5, rats were treated with saline or cisplatin (2 mg kg-1 week-1 , ip). Gastrointestinal motility was measured by radiological methods after f..View full abstract
Awarded by Comunidad Autonoma de Madrid
This work was supported by Fundacion Mapfre (Ayudas a la Investigacion-Promocion de la Salud 2011) to RA and Comunidad Autonoma de Madrid (PEJD-2017-PRE/BMD-3924, predoctoral contract to Y. Lopez-Tofino).