Journal article

Evaluation of Cyto-genotoxicity of Perfluorooctane Sulfonate (PFOS) to Allium cepa

Anithadevi Kenday Sivaram, Panneerselvan Logeshwaran, Aravind Surapaneni, Kalpit Shah, Nicholas Crosbie, Zoe Rogers, Elliot Lee, Kartik Venkatraman, Kurunthachalam Kannan, Ravi Naidu, Mallavarapu Megharaj

Environmental Toxicology and Chemistry | WILEY | Published : 2020

Abstract

Per- and polyfluoroalkyl substances (PFAS) have emerged as contaminants of global concern. Among several PFAS, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are persistent and bioaccumulative compounds. We investigated the cyto-genotoxic potential of PFOS to Allium cepa root meristem cells. The A. cepa root tips were exposed to 6 different concentrations (1-100 mg L-1 ) of PFOS for 48 h. Reduction in mitotic index and chromosomal aberrations was measured as genotoxic endpoints in meristematic root cells. Exposure to PFOS significantly affected cell division by reducing the miotic index at higher concentrations (>10 mg L-1 ). The median effect concentration of PFOS to eli..

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Grants

Awarded by Australian Research Council (ARC) grant under the special research initiative on PFAS


Funding Acknowledgements

The authors acknowledge the Australian Research Council (ARC) grant under the special research initiative on PFAS (SR180100036), including associated industry partners (Acacia Waste Management Solutions, Hunter Water, Melbourne Water, South East Water, New York University, Water Corporation) and the Global Centre for Environmental Remediation, The University of Newcastle, for laboratory facilities.