Journal article

Vitamin D insufficiency is associated with reduced regulatory T cell frequency in food-allergic infants

Melanie R Neeland, Amanda R Tursi, Kirsten P Perrett, Richard Saffery, Jennifer J Koplin, Kari C Nadeau, Sandra Andorf

Pediatric Allergy and Immunology | WILEY | Published : 2021


The influence of vitamin D on human health is strongly associated with tolerogenic immune function, skewing the immune response toward a regulatory phenotype. Ecological and epidemiological studies have resulted in a proposed link between reduced levels of the most abundant circulating form of vitamin D, 25-hydroxyvitamin D (25(OH)D), and the development of food allergy in children.1 We have also shown that infants with vitamin D insufficiency (≤ 50nmol/L) were 11 times more likely to have a peanut allergy and 3 times more likely to have an egg allergy relative to infants with sufficient vitamin D levels.2 Interestingly, in the same cohort, 25(OH)D levels positively correlated with tolerogen..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

The HealthNuts study is supported by funding from the National Health and Medical Research Council of Australia (NHMRC) (Project grant GNT491233), the Ilhan Food Allergy Foundation, AnaphylaxiStop, The Charles and Sylvia Viertel Medical Research Foundation, and the Victorian Government's Operational Infrastructure Support Program. MRN is supported by a Melbourne Children's Lifecourse Postdoctoral Fellowship.