Journal article

The minimum effective dose of abobotulinum toxin A injection for allergic rhinitis: A dose-escalation randomized controlled trial

Patorn Piromchai, Worakit Pornumnouy, Patchareeporn Saeseow, Seksun Chainansamit

Laryngoscope Investigative Otolaryngology | WILEY | Published : 2020

Abstract

Objective: To find the lowest effective injection dose of abobotulinum toxin A (Dysport) for allergic rhinitis. Study Design: Dose-escalation randomized controlled trial. Methods: We included all patients aged 18 years or older who had persistent allergic rhinitis and positive allergy skin prick test. The patients were randomly allocated to receive 40, 30, or 20 U of abobotulinum toxin A by injection at the inferior turbinate. We followed up on patients for 12 weeks to evaluate nasal symptoms, ocular symptoms, minimum nasal cross-sectional area as measured using acoustic rhinometry, and complications. Results: Seventeen patients were included in this study, with 7 receiving 20 U of abobotuli..

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University of Melbourne Researchers

Grants

Awarded by Faculty of Medicine, Khon Kaen University


Funding Acknowledgements

Faculty of Medicine, Khon Kaen University, Grant/Award Numbers: AS63102, IN61148