Journal article

Resting-state functional connectivity and quantitation of glutamate and GABA of the PCC/precuneus by magnetic resonance spectroscopy at 7T in healthy individuals

Ofer M Gonen, Bradford A Moffat, Patrick Kwan, Terence J O'Brien, Patricia M Desmond, Elaine Lui

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2020


The default mode network (DMN) is the main large-scale network of the resting brain and the PCC/precuneus is a major hub of this network. Glutamate and GABA (γ-amino butyric acid) are the main excitatory and inhibitory neurotransmitters in the CNS, respectively. We studied glutamate and GABA concentrations in the PCC/precuneus via magnetic resonance spectroscopy (MRS) at 7T in relation to age and correlated them with functional connectivity between this region and other DMN nodes in ten healthy right-handed volunteers ranging in age between 23-68 years. Mean functional connectivity of the PCC/precuneus to the other DMN nodes and the glutamate/GABA ratio significantly correlated with age (r =..

View full abstract


Funding Acknowledgements

The authors acknowledge the facilities, scientific and technical assistance, and salary support of BAM from the National Imaging Facility, a National Collaborative Research Infrastructure Strategy (NCRIS) capability, at the Melbourne Brain Center Imaging Unit, The University of Melbourne. OGM was supported by the Melbourne Research Scholarship (MRS), The University of Melbourne and The Neuroscience Foundation, The Royal Melbourne Hospital.