Reduced growth velocity from the mid-trimester is associated with placental insufficiency in fetuses born at a normal birthweight.
Lucy M Kennedy, Stephen Tong, Alice J Robinson, Richard J Hiscock, Lisa Hui, Kirsten M Dane, Anna L Middleton, Susan P Walker, Teresa M MacDonald
BMC Medicine | Biomed Central | Published : 2020
BACKGROUND: Fetal growth restriction (FGR) due to placental insufficiency is a major risk factor for stillbirth. While small-for-gestational-age (SGA; weight < 10th centile) is a commonly used proxy for FGR, detection of FGR among appropriate-for-gestational-age (AGA; weight ≥ 10th centile) fetuses remains an unmet need in clinical care. We aimed to determine whether reduced antenatal growth velocity from the time of routine mid-trimester ultrasound is associated with antenatal, intrapartum and postnatal indicators of placental insufficiency among term AGA infants. METHODS: Three hundred and five women had biometry measurements recorded from their routine mid-trimester (20-week) ultrasound, ..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by Department of Health, Australian Government
NHMRC Grant #1065854 to SW; Australian Government Research Training Program Scholarship to TM; Mercy Health Foundation philanthropic funding for purchase of the PEAPOD air displacement plethysmography device. Funding sources had no involvement in study design, collection or analysis of data, or in the writing or submission of this manuscript.