Conference Proceedings

Antiseptic mouthwash for gonorrhoea prevention (OMEGA): a randomised, double-blind, parallel-group, multicentre trial

Eric PF Chow, Deborah A Williamson, Jane S Hocking, Matthew G Law, Kate Maddaford, Catriona S Bradshaw, Anna McNulty, David J Templeton, Richard Moore, Gerald L Murray, Jennifer A Danielewski, Rebecca Wigan, Marcus Y Chen, Rebecca J Guy, Lei Zhang, Basil Donovan, Andrew E Grulich, John M Kaldor, David M Whiley, Vincent J Cornelisse Show all

LANCET INFECTIOUS DISEASES | ELSEVIER SCI LTD | Published : 2021

Abstract

BACKGROUND: To address the increasing incidence of gonorrhoea and antimicrobial resistance, we compared the efficacy of Listerine and Biotène mouthwashes for preventing gonorrhoea among men who have sex with men (MSM). METHODS: The OMEGA trial was a multicentre, parallel-group, double-blind randomised controlled trial among MSM, done at three urban sexual health clinics and one general practice clinic in Australia. Men were eligible if they were diagnosed with oropharyngeal gonorrhoea by nucleic acid amplification test (NAAT) in the previous 30 days or were aged 16-24 years. They were randomly assigned to receive Listerine (intervention) or Biotène (control) via a computer-generated sequence..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by Australian NHMRC Emerging Leadership Investigator Grant


Awarded by Australian NHMRC Leadership Investigator Grant


Awarded by Australian NHMRC Early Career Fellowship


Funding Acknowledgements

This study was funded by a project grant from the Australian National Health and Medical Research Council (NHMRC; GNT1122514) . EPFC and DAW are supported by an Australian NHMRC Emerging Leadership Investigator Grant (GNT1172873 and GNT1174555, respectively) . CKF and CSB are supported by an Australian NHMRC Leadership Investigator Grant (GNT1172900 and GNT1173361, respectively) . TRHR was supported by an Australian NHMRC Early Career Fellowship (GNT1091536) . The authors would like to thank all study participants and staff at recruitment sites: Sandra Walker, Tiffany Phillips, Alison Clough, Lucy Beaton, Sabrina Trumpour, Mark Chung, Afrizal Afrizal, Jun Kit Sze, Ria Fortune, Trish Wakefield, Suzanne Amisano, Helen Hezell, Karen Berzins, Stephen Rowles, Anna Morton, Mark Thompson, Caroline Cittarelli, Surbhi Bird, Luke Mitchell, Susan Rose, and Lauren Bryar at the Melbourne Sexual Health Centre; Ruthy Mclver and Elizabeth Scally at the Sydney Sexual Health Centre; Gary Prott, Amber Ellis, and Linda Garton at Royal Prince Alfred Sexual Health; Sian Edwards and Susan Boyd at Nothside Clinic; Norman Roth at Prahran Market Clinic; Vesna De Petra, Marlene Tschaepe, Kate Frauenfelder, Catherine Flower, Darren Lee, and Melinda Ashcroft at Microbiological Diagnostic Unit Public Health Laboratory at The Peter Doherty Institute for Infection and Immunity; Sepehr Tabrizi at Murdoch Children?s Research Institute; Samuel Phillips at the University of Sunshine Coast; Monica Lahra from WHO Collaborating Centre for Sexually Transmitted Infections and Antimicrobial Resistance, NSW Health Pathology, Microbiology.