Enhanced T Cell Responses Induced by a Necrotic Dendritic Cell Vaccine, Expressing HCV NS3
Zelalem A Mekonnen, Makutiro G Masavuli, Wenbo Yu, Jason Gummow, Dawn M Whelan, Zahraa Al-Delfi, Joseph Torresi, Eric J Gowans, Branka Grubor-Bauk
Frontiers in Microbiology | FRONTIERS MEDIA SA | Published : 2020
A vaccine that induces potent, broad and sustained cell-mediated immunity, resulting in effective memory has the potential to restrict hepatitis C (HCV) virus infection. Early, multi-functional CD4+ and CD8+ T cell responses against non-structural protein 3 (NS3) have been associated with HCV clearance. Necrotic cells generate strong immune responses and represent a major antigenic source used by dendritic cells (DC) for processing and presentation, but there is conflicting evidence as to their immunogenicity in vaccination. Immunization with DC loaded with viral antigens has been done in the past, but to date the immunogenicity of live vs. necrotic DC vaccines has not been investigated. We ..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
Awarded by Australian-Indian biotechnology fund
This research was supported by grants 543139 and 543143 from the National Health and Medical Research Council (NHMRC) of Australia, grant BF040005 from the Australian-Indian biotechnology fund, and a grant from the Hospital Research Foundation (THRF).