Journal article

Adverse events related to antiepileptic drugs

Yew Li Dang, Emma Foster, Michael Lloyd, Genevieve Rayner, Maria Rychkova, Rashida Ali, Patrick W Carney, Dennis Velakoulis, Toby T Winton-Brown, Tomas Kalincik, Piero Perucca, Terence J O'Brien, Patrick Kwan, Charles B Malpas

Epilepsy & Behavior | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2021

Abstract

OBJECTIVE: Adverse events (AEs) related to antiepileptic drugs (AEDs) may interfere with adequate dosing and patient adherence, leading to suboptimal seizure control, and relatedly, increased injuries, hospitalizations, and mortality. This study investigated the clinicodemographic factors associated with AEs related to AEDs as reported by the Liverpool Adverse Events Profile (LAEP), and explored the ability of LAEP to discriminate between epilepsy and psychogenic nonepileptic seizures (PNES). We hypothesized that female sex, mood disorders, AED-polytherapy, duration, and severity of epilepsy are associated with increased endorsement of AEs related to AEDs, and that endorsement of AEs related..

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