Journal article
Removing high-frequency oscillations: A prospective multicenter study on seizure outcome
J Jacobs, JY Wu, P Perucca, R Zelmann, M Mader, F Dubeau, GW Mathern, A Schulze-Bonhage, J Gotman
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018
Abstract
OBJECTIVE: To evaluate the use of interictal high-frequency oscillations (HFOs) in epilepsy surgery for prediction of postsurgical seizure outcome in a prospective multicenter trial. METHODS: We hypothesized that a seizure-free outcome could be expected in patients in whom the surgical planning included the majority of HFO-generating brain tissue while a poor seizure outcome could be expected in patients in whom only a few such areas were planned to be resected. Fifty-two patients were included from 3 tertiary epilepsy centers during a 1-year period. Ripples (80-250 Hz) and fast ripples (250-500 Hz) were automatically detected during slow-wave sleep with chronic intracranial EEG in 2 centers..
View full abstractGrants
Awarded by German Research Foundation (DFG)
Awarded by NIH
Awarded by Canadian Institutes of Health Research
Funding Acknowledgements
J.J. was supported by the German Research Foundation (DFG grant JA1725/2-1). J.Y.W. was supported by the Tuberous Sclerosis Alliance, Novartis Pharmaceuticals Inc, Today's and Tomorrow's Children Fund, Department of Defense/Congressionally Directed Medical Research Program, and the NIH (P20-NS080199, U01-NS082320, R01-NS082649, U54-NS092090, and U01-NS092595). The Montreal Neurologic Institute group was supported by grant FDN 143208 of the Canadian Institutes of Health Research.