Journal article

T Cell Primary Effusion Lymphoma in an HIV-Negative Man with Liver Cirrhosis.

Jacqueline Kropf, Mina Gerges, Ariel Perez Perez, Austin Ellis, Mevin Mathew, Kwabena Ayesu, Li Ge, Steve J Carlan

Am J Case Rep | Published : 2020

Abstract

BACKGROUND Primary effusion lymphoma (PEL) is a rare and aggressive non-Hodgkin lymphoma (NHL) that is responsible for 1% of all lymphomas not related to human immunodeficiency virus (HIV). PEL is characterized by human herpesvirus-8 (HHV-8) positivity in the absence of overt tumor burden that does not exhibit typical B cell or T cell immunophenotype characteristics. The exact mechanism of development is unknown, but it is hypothesized to develop from post-germinal B cell origin. Although it is most common in HIV patients, other immunocompromising comorbidities can be seen in conjunction with PEL, including liver cirrhosis. CASE REPORT We present the case of a 73-year-old HIV-seronegative ma..

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University of Melbourne Researchers