T cell primary effusion lymphoma in an hiv-negative man with liver cirrhosis

Abstract

Objective: Rare disease Background: Primary effusion lymphoma (PEL) is a rare and aggressive non-Hodgkin lymphoma (NHL) that is responsible for 1% of all lymphomas not related to human immunodeficiency virus (HIV). PEL is characterized by human herpesvirus-8 (HHV-8) positivity in the absence of overt tumor burden that does not exhibit typical B cell or T cell immunophenotype characteristics. The exact mechanism of development is unknown, but it is hypothe-sized to develop from post-germinal B cell origin. Although it is most common in HIV patients, other immuno-compromising comorbidities can be seen in conjunction with PEL, including liver cirrhosis. Case Report: We present the case of a 73-..