Journal article

Systemic Inflammation Suppresses Lymphoid Tissue Remodeling and B Cell Immunity during Concomitant Local Infection

Yannick O Alexandre, Sapna Devi, Simone L Park, Laura K Mackay, William R Heath, Scott N Mueller

Cell Reports | CELL PRESS | Published : 2020


Concurrent infection with multiple pathogens occurs frequently in individuals and can result in exacerbated infections and altered immunity. However, the impact of such coinfections on immune responses remains poorly understood. Here, we reveal that systemic infection results in an inflammation-induced suppression of local immunity. During localized infection or vaccination in barrier tissues including the skin or respiratory tract, concurrent systemic infection induces a type I interferon-dependent lymphopenia that impairs lymphocyte recruitment to the draining lymph node (dLN) and induces sequestration of lymphocytes in non-draining LN. This contributes to suppressed fibroblastic reticular..

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Funding Acknowledgements

We thank Paul Hertzog (Hudson Institute, Australia) for anti-IFNAR antibody, Hidde Ploegh (Whitehead Institute, Cambridge, MA) for OBI mice, Genentech for anti-mouse CD20 antibody, the Biological Optical Microscopy Platform (BOMP) for support, and Yu Kato for advice on HSV ELISA. This work was supported by the National Health and Medical Research Council of Australia and the Australian Research Council (to L.K.M., W.R.H., and S.N.M.).