Systemic Inflammation Suppresses Lymphoid Tissue Remodeling and B Cell Immunity during Concomitant Local Infection

YO Alexandre; S Devi; SL Park; LK Mackay; WR Heath; SN Mueller

Journal article

Systemic Inflammation Suppresses Lymphoid Tissue Remodeling and B Cell Immunity during Concomitant Local Infection

YO Alexandre, S Devi, SL Park, LK Mackay, WR Heath, SN Mueller

Cell Reports | Published : 2020

DOI: 10.1016/j.celrep.2020.108567

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Abstract

Alexandre et al. reveal that systemic inflammation occurring concomitant with a localized infection or vaccination impairs the capacity to induce regional immunity. Inflammation-dependent lymphopenia impairs lymphocyte recruitment to draining lymph nodes and suppresses local tissue remodeling and B cell responses.

University of Melbourne Researchers

Yannick Alexandre Author

Sapna Devi Author

Laura Mackay Author

William Heath Author

Grants

Funding Acknowledgements

We thank Paul Hertzog (Hudson Institute, Australia) for anti-IFNAR antibody, Hidde Ploegh (Whitehead Institute, Cambridge, MA) for OBI mice, Genentech for anti-mouse CD20 antibody, the Biological Optical Microscopy Platform (BOMP) for support, and Yu Kato for advice on HSV ELISA. This work was supported by the National Health and Medical Research Council of Australia and the Australian Research Council (to L.K.M., W.R.H., and S.N.M.).