Journal article

Systematic quantification of histologic ventricular fibrosis in isolated mitral valve prolapse and sudden cardiac death

Hui-Chen Han, Sarah A Parsons, Claire L Curl, Andrew W Teh, Antonia JA Raaijmakers, Anoop N Koshy, Trishe Leong, Louise M Burrell, David O'Donnell, Jitendra K Vohra, Jonathan M Kalman, Prashanthan Sanders, David L Hare, Omar Farouque, Lea MD Delbridge, Han S Lim



BACKGROUND: Cardiac fibrosis in mitral valve prolapse (MVP) is implicated in the development of sudden cardiac death (SCD); however, the pattern remains poorly characterized. OBJECTIVE: The purpose of this study was to systematically quantify left and right ventricular fibrosis in individuals with isolated MVP and SCD (iMVP-SCD), whereby other potential causes of death are excluded, compared to a control cohort. METHODS: Individuals with iMVP-SCD were identified from the Victorian Institute of Forensic Medicine, Australia, and matched for age, sex, and body mass index to control cases with noncardiac death. Cardiac tissue sections were analyzed to determine collagen deposition in the left ve..

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Awarded by Austin Medical Research Foundation

Funding Acknowledgements

This work is supported by the Austin Medical Research Foundation (Grant Number 2-1252).