Journal article

Bacterial Redox Potential Powers Controlled Radical Polymerization

Mitchell D Nothling, Hanwei Cao, Thomas G McKenzie, Dianna M Hocking, Richard A Strugnell, Greg G Qiao

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | AMER CHEMICAL SOC | Published : 2021

Abstract

Microbes employ a remarkably intricate electron transport system to extract energy from the environment. The respiratory cascade of bacteria culminates in the terminal transfer of electrons onto higher redox potential acceptors in the extracellular space. This general and inducible mechanism of electron efflux during normal bacterial proliferation leads to a characteristic fall in bulk redox potential (Eh), the degree of which is dependent on growth phase, the microbial taxa, and their physiology. Here, we show that the general reducing power of bacteria can be subverted to induce the abiotic production of a carbon-centered radical species for targeted bioorthogonal molecular synthesis. Usin..

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Grants

Awarded by Australian Research Council


Awarded by NHMRC


Funding Acknowledgements

The authors acknowledge the generous advice provided by Prof. Anne S. Meyer and Prof. Andreas J. Baumler and the technical support provided by Nicole Lau and Leila Jebeli. This work was supported by the Australian Research Council under the Discovery Project scheme (DP170104321) (G.G.Q. & R.A.S.), an NHMRC Program Grant APP1092262 (NHMRC Program in Cellular Microbiology (R.A.S., D.M.H.)), and the Veski Victoria Fellowship (M.D.N.).