Mycobacterium ulcerans-specific immune response after immunisation with bacillus Calmette-Guerin (BCG) vaccine

Laure F Pittet; Marc Tebruegge; Binita Dutta; Susan Donath; Nicole Messina; Dan Casalaz; Willem A Hanekom; Warwick J Britton; Roy Robins-Browne; Nigel Curtis; Nicole Ritz

Journal article

Mycobacterium ulcerans-specific immune response after immunisation with bacillus Calmette-Guerin (BCG) vaccine

Laure F Pittet, Marc Tebruegge, Binita Dutta, Susan Donath, Nicole Messina, Dan Casalaz, Willem A Hanekom, Warwick J Britton, Roy Robins-Browne, Nigel Curtis, Nicole Ritz

Vaccine | ELSEVIER SCI LTD | Published : 2021

DOI: 10.1016/j.vaccine.2020.11.045

Abstract

BACKGROUND: Bacillus Calmette-Guérin (BCG) vaccine provides partial protection against Buruli ulcer caused by Mycobacterium ulcerans in epidemiological studies. This study aimed to quantify M. ulcerans-specific immune responses induced by BCG immunisation. METHODS: Intracellular cytokine analysis of in-vitro experiments done 10 weeks after BCG immunisation in 130 Australian infants randomised to one of three BCG vaccine strains given either at birth (BCG-Denmark, BCG-Japan, or BCG-Russia) or at two months of age (BCG-Denmark). RESULTS: Proportions of polyfunctional CD4+ T-cells were higher in M. ulcerans-stimulated compared to unstimulated control samples. These proportions were not influenc..

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