Journal article

Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection

M Muenchhoff, AW Chung, J Roider, Anne-Sophie Dugast, Simone Richardson, Henrik Kloverpris, Alasdair Leslie, Thumbi Ndung'u, Penny Moore, Galit Alter, Philip JR Goulder

mSphere | AMER SOC MICROBIOLOGY | Published : 2020

Abstract

A prophylactic HIV vaccine would ideally induce protective immunity prior to sexual debut. Children develop broadly neutralizing antibody (bnAb) responses faster and at higher frequencies than adults, but little is known about the underlying mechanisms or the potential role of Fc-mediated effector functions in disease progression. We therefore performed systems immunology, with immunoglobulin profiling, on HIV-infected children with progressive and nonprogressive disease. Pediatric nonprogressors (PNPs) showed distinct immunoglobulin profiles with an increased ability to elicit potent Fc-mediated natural killer (NK)-cell effector functions. In contrast to previous reports in adults, both gro..

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University of Melbourne Researchers