Journal article

Characteristics and outcomes of participants in colorectal cancer biomarker trials versus a real-world cohort

Siavash Foroughi, Hui-li Wong, Jeanne Tie, Rachel Wong, Margaret Lee, Belinda Lee, Ian Jones, Iain Skinner, Antony W Burgess, Peter Gibbs

Acta Oncologica | TAYLOR & FRANCIS LTD | Published : 2020


BACKGROUND: The restrictive eligibility criteria of therapy-focused cancer clinical trials can limit the external validity of the results. The characteristics and survival outcomes of patients enrolled in stand-alone biomarker studies have yet to be explored. We examined the characteristics of patients enrolled in a series of biomarker studies in stage II and III colorectal cancer (CRC) and of the broader patient population from which the study cohorts were recruited. MATERIAL AND METHODS: We examined three distinct trial scenarios: a retrospective cohort study (RCS) where archival tissue samples were analyzed, a prospective observational study (POS) where blood samples were collected but pa..

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Funding Acknowledgements

This work was supported by an Australian Government Research Training Program Scholarship (to SF).