Wolbachia strain wAlbB maintains high density and dengue inhibition following introduction into a field population of Aedes aegypti
Noor Afizah Ahmad, Maria-Vittoria Mancini, Thomas H Ant, Julien Martinez, Ghazali MR Kamarul, Wasi A Nazni, Ary A Hoffmann, Steven P Sinkins
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | ROYAL SOC | Published : 2021
Aedes aegypti mosquitoes carrying the wAlbB Wolbachia strain show a reduced capacity to transmit dengue virus. wAlbB has been introduced into wild Ae. aegypti populations in several field sites in Kuala Lumpur, Malaysia, where it has persisted at high frequency for more than 2 years and significantly reduced dengue incidence. Although these encouraging results indicate that wAlbB releases can be an effective dengue control strategy, the long-term success depends on wAlbB maintaining high population frequencies and virus transmission inhibition, and both could be compromised by Wolbachia-host coevolution in the field. Here, wAlbB-carrying Ae. aegypti collected from the field 20 months after t..View full abstract
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Awarded by Wellcome Trust
Awarded by NHMRC
The study was funded by Wellcome Trust awards 108508 and 202888 and NHMRC 1118640.