Mouse models illuminate MAIT cell biology

H Wang; Z Chen; J McCluskey; AJ Corbett

Journal article

Mouse models illuminate MAIT cell biology

H Wang, Z Chen, J McCluskey, AJ Corbett

Molecular Immunology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021

DOI: 10.1016/j.molimm.2020.12.007

Abstract

The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based antigens recognised by these specialised T cells. Over the past few years, our understanding of the complexities of MAIT cell function has developed, as they find their place among the other better known cells of the immune system. Key questions relate to understanding when MAIT cells help, when they hinder or cause harm, and when they do not matter. Exploiting mouse strains that differ in MAIT cell numbers, leveraged by specific detection of MAIT cells using MR1-tetramers, it has now been shown that MAIT cells play important immune roles in settings that include ..

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University of Melbourne Researchers

Huimeng Wang Author

Zhenjun Chen Author

James McCluskey Author

Alexandra Corbett Author

Related Projects (3)

ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

Understanding recognition of vitamin B-based antigens by the immune system

This project aims to evaluate the range of molecules that can stimulate vitamin B-reactive T cells in mammals and amphibians, and the degree..

A STRUCTURAL, CHEMICAL AND FUNCTIONAL INVESTIGATION INTO MAIT CELL RECEPTOR RECOGNITION

This project is focused on a type of T-cell, termed a MAIT cell, which is found abundantly in the lining of the gut. We are investigating ho..

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

AJC is supported by a Future Fellowship (FT160100083) from the Australian Research Council (ARC). The authors are supported by research grants from the National Health and Medical Research Council of Australia (NHMRC) (1113293, 1125493) and the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health (NIH) (R01AI148407). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, NHMRC or ARC.