Journal article

Mouse models illuminate MAIT cell biology

Huimeng Wang, Zhenjun Chen, James McCluskey, Alexandra J Corbett

MOLECULAR IMMUNOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021

Abstract

The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based antigens recognised by these specialised T cells. Over the past few years, our understanding of the complexities of MAIT cell function has developed, as they find their place among the other better known cells of the immune system. Key questions relate to understanding when MAIT cells help, when they hinder or cause harm, and when they do not matter. Exploiting mouse strains that differ in MAIT cell numbers, leveraged by specific detection of MAIT cells using MR1-tetramers, it has now been shown that MAIT cells play important immune roles in settings that include ..

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Grants

Awarded by Australian Research Council (ARC)


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by National Institute Of Allergy And Infectious Diseases of the National Institutes of Health (NIH)


Funding Acknowledgements

AJC is supported by a Future Fellowship (FT160100083) from the Australian Research Council (ARC). The authors are supported by research grants from the National Health and Medical Research Council of Australia (NHMRC) (1113293, 1125493) and the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health (NIH) (R01AI148407). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, NHMRC or ARC.