Journal article
Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2
AE Horner, RH Norris, R McLaren-Jones, L Alexander, NH Komiyama, SGN Grant, J Nithianantharajah, MV Kopanitsa
Genes Brain and Behavior | WILEY | Published : 2021
DOI: 10.1111/gbb.12723
Abstract
The postsynaptic terminal of vertebrate excitatory synapses contains a highly conserved multiprotein complex that comprises neurotransmitter receptors, cell-adhesion molecules, scaffold proteins and enzymes, which are essential for brain signalling and plasticity underlying behaviour. Increasingly, mutations in genes that encode postsynaptic proteins belonging to the PSD-95 protein complex, continue to be identified in neurodevelopmental disorders (NDDs) such as autism spectrum disorder, intellectual disability and epilepsy. These disorders are highly heterogeneous, sharing genetic aetiology and comorbid cognitive and behavioural symptoms. Here, by using genetically engineered mice and innov..
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Awarded by Medical Research Council
Funding Acknowledgements
Australian Federal Government, Grant/Award Number: Australian Postgraduate Research Training Award; Australian Research Council, Grant/Award Number: Future Fellowship 140101327; H2020 European Research Council, Grant/Award Number: 695568 SYNNOVATE; Medical Research Council, Grant/Award Number: UK Dementia Research Institute at Imperial College; National Health and Medical Research Council, Grant/Award Numbers: 1083334, 1163504; Seventh Framework Programme, Grant/Award Number: grant agreement No 604102 (Human Brain project); Simons Foundation Autism Research Initiative, Grant/Award Number: 529085; Wellcome Trust, Grant/Award Number: Technology Development Grant 202932