Journal article

Prolonged Survival Following Lung Transplantation in the Absence of Conventional Immunosuppression

GP Westall, B Bourne, M Paraskeva, S Harrison, G Snell

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation | Published : 2020

Abstract

PURPOSE: The modern era of lung transplantation (LTx) coincided with the discovery of the calceneurin inhibitors and the ability to limit the the immune response to LTx. Most LTx recipients are maintained on triple immunosuppression. Prolonged survival without conventional immunosuppression has not been reported. METHODS: We report extended survival following LTx in a recipient who has not received oral immunosuppression for over 2 years and is only maintained on 4-weekly extracorporeal photophoresis (ECP) and intravenous immunoglobulin (IVIg). RESULTS: The index case is a 13 year old male with cystic fibrosis who underwent LTx in 2015. He was colonized with mycobacterium abscessus pre-LTx a..

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