Journal article
Comparative genomics revealed adaptive admixture in cryptosporidium hominis in Africa
S Tichkule, AR Jex, C van Oosterhout, AR Sannella, R Krumkamp, C Aldrich, O Maiga-Ascofare, D Dekker, M Lamshöft, J Mbwana, N Rakotozandrindrainy, S Borrmann, T Thye, K Schuldt, D Winter, PG Kremsner, K Oppong, P Manouana, M Mbong, S Gesase Show all
Microbial Genomics | MICROBIOLOGY SOC | Published : 2021
Open access
Abstract
Cryptosporidiosis is a major cause of diarrhoeal illness among African children, and is associated with childhood mortality, malnutrition, cognitive development and growth retardation. Cryptosporidium hominis is the dominant pathogen in Africa, and genotyping at the glycoprotein 60 (gp60) gene has revealed a complex distribution of different subtypes across this conti-nent. However, a comprehensive exploration of the metapopulation structure and evolution based on whole-genome data has yet to be performed. Here, we sequenced and analysed the genomes of 26 C. hominis isolates, representing different gp60 subtypes, collected at rural sites in Gabon, Ghana, Madagascar and Tanzania. Phylogenetic..
View full abstractGrants
Awarded by State Government of Victoria
Funding Acknowledgements
This work was financially supported by the European Union Horizon 2020 Research and Innovation Programme COMPARE (grant mumber 643476) to S. M. C. and the German Research Foundation (DFG) to D. E. A. R. J. acknowledges financial support from the Australian National Health and Medical Research Council (APP1126395) and Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme. C. v. O. was supported by the Earth and Life Systems Alliance. S. T. was supported by Walter and Eliza Hall International PhD Scholarship and Melbourne Research Scholarship (MRS). M. B. is funded by an NHMRC Senior Research Fellowship (ID: 1102971).