Comparative genomics revealed adaptive admixture in Cryptosporidium hominis in Africa
Swapnil Tichkule, Aaron R Jex, Cock van Oosterhout, Anna Rosa Sannella, Ralf Krumkamp, Cassandra Aldrich, Oumou Maiga-Ascofare, Denise Dekker, Maike Lamshoeft, Joyce Mbwana, Njari Rakotozandrindrainy, Steffen Borrmann, Thorsten Thye, Kathrin Schuldt, Doris Winter, Peter G Kremsner, Kwabena Oppong, Prince Manouana, Mirabeau Mbong, Samwel Gesase Show all
Microbial Genomics | MICROBIOLOGY SOC | Published : 2021
Cryptosporidiosis is a major cause of diarrhoeal illness among African children, and is associated with childhood mortality, malnutrition, cognitive development and growth retardation. Cryptosporidium hominis is the dominant pathogen in Africa, and genotyping at the glycoprotein 60 (gp60) gene has revealed a complex distribution of different subtypes across this continent. However, a comprehensive exploration of the metapopulation structure and evolution based on whole-genome data has yet to be performed. Here, we sequenced and analysed the genomes of 26 C. hominis isolates, representing different gp60 subtypes, collected at rural sites in Gabon, Ghana, Madagascar and Tanzania. Phylogenetic ..View full abstract
Awarded by European Union Horizon 2020 Research and Innovation Programme COMPARE
Awarded by Australian National Health and Medical Research Council
Awarded by Melbourne Research Scholarship (MRS) - NHMRC Senior Research Fellowship
This work was financially supported by the European Union Horizon 2020 Research and Innovation Programme COMPARE (grant mumber 643476) to S. M. C. and the German Research Foundation (DFG) to D. E. A. R. J. acknowledges financial support from the Australian National Health and Medical Research Council (APP1126395) and Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme. C. v. O. was supported by the Earth and Life Systems Alliance. S. T. was supported by Walter and Eliza Hall International PhD Scholarship and Melbourne Research Scholarship (MRS). M. B. is funded by an NHMRC Senior Research Fellowship (ID: 1102971).