Journal article

RTS,S/AS01(E) malaria vaccine induces IgA responses against CSP and vaccine-unrelated antigens in African children in the phase 3 trial

Roger Suau, Marta Vidal, Ruth Aguilar, Gemma Ruiz-Olalla, Miquel Vazquez-Santiago, Chenjerai Jairoce, Augusto J Nhabomba, Gyan Ben, David Dosoo, Kwaku Poku Asante, Seth Owusu-Agyei, Joseph J Campo, Luis Izquierdo, David Cavanagh, Ross L Coppel, Virander Chauhan, Evelina Angov, Sheetij Dutta, Deepak Gaur, James G Beeson Show all

VACCINE | ELSEVIER SCI LTD | Published : 2021

Abstract

BACKGROUND: The evaluation of immune responses to RTS,S/AS01 has traditionally focused on immunoglobulin (Ig) G antibodies that are only moderately associated with protection. The role of other antibody isotypes that could also contribute to vaccine efficacy remains unclear. Here we investigated whether RTS,S/AS01E elicits antigen-specific serum IgA antibodies to the vaccine and other malaria antigens, and we explored their association with protection. METHODS: Ninety-five children (age 5-17 months old at first vaccination) from the RTS,S/AS01E phase 3 clinical trial who received 3 doses of RTS,S/AS01E or a comparator vaccine were selected for IgA quantification 1 month post primary immuniza..

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Grants

Awarded by NIH-NIAID


Awarded by Ministerio de Economia y Competitividad (Instituto de Salud Carlos III)


Awarded by Department of Health, Catalan Government


Awarded by National Health and Medical Research Council of Australia


Awarded by Spanish Ministry of Science and Innovation


Funding Acknowledgements

Funding was obtained from the NIH-NIAID (R01AI095789), PATH Malaria Vaccine Initiative (MVI), Ministerio de Economia y Competitividad (Instituto de Salud Carlos III, PI11/00423 and PI17/02044). GM had the support of the Department of Health, Catalan Government (SLT006/17/00109). JGB was supported by a Senior Research Fellowship of the National Health and Medical Research Council of Australia (1077636). This research is part of the ISGlobal's Program on the Molecular Mechanisms of Malaria which is partially supported by the Fundacion Ramon Areces. We acknowledge support from the Spanish Ministry of Science and Innovation through the ``Centro de Excelencia Severo Ochoa 2019-2023"Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.