Journal article

In utero exposure to maternal stressful life events and risk of polycystic ovary syndrome in the offspring: The Raine Study

T Koch, DA Doherty, JE Dickinson, A Juul, R Hart, EV Brauner, M Hickey



BACKGROUND: PCOS is the most common endocrine disorder in reproductive age women. The origins of PCOS are unknown but experimental and limited human evidence suggests that greater prenatal exposure to androgens may predispose to PCOS. Experimental evidence suggests that maternal stressors may affect reproductive function in the offspring via changes in prenatal androgen exposure. In this present study, we aim to investigate whether maternal stressful life events during pregnancy are associated with polycystic ovary morphology (PCOM) or polycystic ovary syndrome (PCOS) in adolescent offspring. METHOD: In a large population-based pregnancy cohort study (The Raine Study) continuously followed f..

View full abstract


Awarded by NHMRC

Funding Acknowledgements

The core management of the Raine Study is funded by University of Western Australia, Curtin University, Telethon Kids Institute, Women and Infants Research Foundation, Edith Cowan University, Murdoch University, The University of Notre Dame Australia and Raine Medical Research foundation for providing funding to core management of the Raine Study. The Raine Study Gen2-14 year follow-up: NHMRC (Sly et al., ID 211912); NHMRC Program Grant (Stanley et al., ID 003209); The Raine Medical Research Foundation. Dr. Brauner' and Trine Koch's salaries were supported by Doctor Sofus Carl Emil Friis and spouse Olga Doris Friis foundation in Denmark and Helsefonden. Martha Hickey is funded by an NHMRC Practitioner Fellowship.