Management of inflammatory neurologic and psychiatric manifestations of systemic lupus erythematosus: A systematic review

Abstract

Background: The neurological and psychiatric manifestations of systemic lupus erythematosus (NPSLE) are a heterogeneous group of conditions with variable clinical presentation and significant morbidity and mortality. Objectives: Our aim was to comprehensively assess and present the evidence for treatments used in the management of inflammatory NPSLE. Methods: Medline, Embase, CINHAL and Cochrane CENTRAL were searched from 1990 to end of March 2019 using key words that related to NPSLE and treatment. Included studies comprised clinical trials, observational studies or case series with ≥5 patients and sufficient data related to treatment and outcome in NPSLE patients. Results: There were 7222 ..