A multi-institutional outbreak of New Delhi metallo-β-lactamase-producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene.
Ester Solter, Jason C Kwong, Aaron Walton, Norelle Sherry, Benjamin P Howden, M Lindsay Grayson, David Schwartz, Elizabeth Temkin, Sammy Frenk, Yehuda Carmeli, Mitchell J Schwaber
Infection Control and Hospital Epidemiology | Published : 2020
We characterized 57 isolates from a 2-phase clonal outbreak of New Delhi metallo-β-lactamase-producing Eschericha coli, involving 9 Israeli hospitals; all but 1 isolate belonged to sequence-type (ST) 410. Most isolates in the second phase harbored blaKPC-2 in addition to blaNDM-5. Genetic sequencing revealed most dual-carbapenemase-producing isolates to be monophyletically derived from a common ancestor.