Disability accrual in primary and secondary progressive multiple sclerosis

Sam Harding-Forrester; Izanne Roos; Ai-Lan Nguyen; Charles B Malpas; Ibrahima Diouf; Nahid Moradi; Sifat Sharmin; Guillermo Izquierdo; Sara Eichau; Francesco Patti; Dana Horakova; Eva Kubala Havrdova; Alexandre Prat; Marc Girard; Pierre Duquette; Francois Grand Maison; Marco Onofrj; Alessandra Lugaresi; Pierre Grammond; Serkan Ozakbas; Maria Pia Amato; Oliver Gerlach; Patrizia Sola; Diana Ferraro; Katherine Buzzard; Olga Skibina; Jeannette Lechner-Scott; Raed Alroughani; Cavit Boz; Vincent Van Pesch; Elisabetta Cartechini; Murat Terzi; Davide Maimone; Cristina Ramo-Tello; Bassem Yamout; Samia Joseph Khoury; Daniele La Spitaleri; Maria Jose Sa; Yolanda Blanco; Franco Granella; Mark Slee; Ernest Butler; Youssef Sidhom; Riadh Gouider; Roberto Bergamaschi; Rana Karabudak; Radek Ampapa; Jose Luis Sanchez-Menoyo; Julie Prevost; Tamara Castillo-Trivino; Pamela A McCombe; Richard Macdonell; Guy Laureys; Liesbeth Van Hijfte; Jiwon Oh; Ayse Altintas; Koen de Gans; Recai Turkoglu; Anneke van der Walt; Helmut Butzkueven; Steve Vucic; Michael Barnett; Edgardo Cristiano; Suzanne Hodgkinson; Gerardo Iuliano; Ludwig Kappos; Jens Kuhle; Vahid Shaygannejad; Aysun Soysal; Bianca Weinstock-Guttman; Bart Van Wijmeersch; Tomas Kalincik

Journal article

Disability accrual in primary and secondary progressive multiple sclerosis

Sam Harding-Forrester, Izanne Roos, Ai-Lan Nguyen, Charles B Malpas, Ibrahima Diouf, Nahid Moradi, Sifat Sharmin, Guillermo Izquierdo, Sara Eichau, Francesco Patti, Dana Horakova, Eva Kubala Havrdova, Alexandre Prat, Marc Girard, Pierre Duquette, Francois Grand Maison, Marco Onofrj, Alessandra Lugaresi, Pierre Grammond, Serkan Ozakbas Show all

Journal of Neurology, Neurosurgery and Psychiatry | BMJ Publishing Group | Published : 2023

DOI: 10.1136/jnnp-2022-330726

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Abstract

Background: Some studies comparing primary and secondary progressive multiple sclerosis (PPMS, SPMS) report similar ages at onset of the progressive phase and similar rates of subsequent disability accrual. Others report later onset and/or faster accrual in SPMS. Comparisons have been complicated by regional cohort effects, phenotypic differences in sex ratio and management and variable diagnostic criteria for SPMS. Methods: We compared disability accrual in PPMS and operationally diagnosed SPMS in the international, clinic-based MSBase cohort. Inclusion required PPMS or SPMS with onset at age ≥18 years since 1995. We estimated Andersen-Gill hazard ratios for disability accrual on the Expa..

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University of Melbourne Researchers

Izanne Roos Author

Ai-Lan Nguyen Author

Charles Malpas Author

Ibrahima Diouf Author

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Grants

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This study was financially supported by the National Health and Medical Research Council of Australia (1129189, 1140766). The MS Base Foundation is a not- for- profit organisation that has received support from Biogen, CSL, Merck, Novartis, Roche, Sanofi and Teva; this study was conducted independently of the sponsors.