Functionalised polycaprolactone films and 3D scaffolds via gamma irradiation-induced grafting
Jing Zhong Luk, Justin Cooper-White, Llew Rintoul, Elena Taran, Lisbeth Grondahl
Journal of Materials Chemistry B | ROYAL SOC CHEMISTRY | Published : 2013
Polycaprolactone (PCL) is frequently used as the base polymer in scaffolds targeted for tissue engineering applications. However, in the absence of further surface modification, the lack of functional moieties on the PCL chain results in non-ideal surface properties of such scaffolds, especially in terms of the inability to tailor the presentation of functional ligands for directed cell adhesion and growth. The current study investigates gamma irradiation-induced grafting as a means of improving the biofunctionality of the PCL surface. The surface presentation of carboxylic acid groups on 2D PCL films could be tailored by changing the acrylic acid (AAc) concentration and/or the solvent durin..View full abstract
Awarded by Australian Research Council
The authors would like to acknowledge Dr Barry Wood for his assistance in XPS analysis and Dr Grant Edwards for his assistance with compression testing. This work was performed in part at the Queensland node of the Australian National Fabrication Facility, a company established under the National Collaborative Research Infrastructure Strategy to provide nano and microfabrication facilities for Australia's researchers; and Centre for Microscopy and Microanalysis, University of Queensland node of Australian Microscopy and Microanalysis Research Facility (AMMRF). The authors would like to acknowledge partial funding of this project from the Australian Research Council's Discovery Grants Scheme (DP1095429).