Journal article

In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites

Yosephine Andriani, Isabel C Morrow, Elena Taran, Grant A Edwards, Tara L Schiller, Azlin F Osman, Darren J Martin

Acta Biomaterialia | ELSEVIER SCI LTD | Published : 2013


We have prepared a number of silicone-based thermoplastic polyurethane (TPU) nanocomposites and demonstrated an enhancement of in vitro biostability against metal-ion-induced oxidation for potential use in long-term implantable medical devices. Organoclays based on both low-aspect-ratio hectorites and high-aspect-ratio fluoromicas were evaluated after being dual-modified with two quaternary alkyl ammonium salts with differing degrees of polarity. The resultant nanocomposites were tested for in vitro biostability using physiologically relevant oxidizing conditions. Subsequently, the effects of oxidative treatment on the surface degradation and bulk mechanical integrity of the nanocomposites w..

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University of Melbourne Researchers


Funding Acknowledgements

The authors thank Aortech Biomaterials Pty Ltd. and Cochlear (TM) Ltd. for providing research materials and financial support. The facilities and technical assistance from Australian National Fabrication Facility Queensland Node at The University of Queensland are acknowledged. The authors acknowledge the facilities and technical assistance from the Australian Microscopy & Microanalysis Research Facility at the Centre for Microscopy and Microanalysis, The University of Queensland. We also would like to thank Dr. Ajay Padsalgikar and Ms jadwiga Weksler for valued discussions.