Journal article

Metabolomic Biomarkers of Multiple Sclerosis: A Systematic Review

Lachlan Porter, Alireza Shoushtarizadeh, George A Jelinek, Chelsea R Brown, Chai K Lim, Alysha M de Livera, Kelly R Jacobs, Tracey J Weiland

FRONTIERS IN MOLECULAR BIOSCIENCES | FRONTIERS MEDIA SA | Published : 2020

Abstract

Background: Magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, and the McDonald's clinical criteria are currently utilized tools in diagnosing multiple sclerosis. However, a more conclusive, consistent, and efficient way of diagnosing multiple sclerosis (MS) is yet to be discovered. A potential biomarker, discovered using advances in high-throughput sequencing such as nuclear magnetic resonance (NMR) spectroscopy and other "Omics"-based techniques, may make diagnosis and prognosis more reliable resulting in a more personalized and targeted treatment regime and improved outcomes. The aim of this review was to systematically search the literature for potential biomarkers fro..

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