Journal article

Running to Stand Still: Naive CD8( ) T Cells Actively Maintain a Program of Quiescence

Taylah J Bennett, Vibha AV Udupa, Stephen J Turner

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2020

Abstract

CD8+ T cells play a pivotal role in clearing intracellular pathogens and combatting tumours. Upon infection, naïve CD8+ T cells differentiate into effector and memory cells, and this program is underscored by large-scale and coordinated changes in the chromatin architecture and gene expression. Importantly, recent evidence demonstrates that the epigenetic mechanisms that regulate the capacity for rapid effector function of memory T cells are shared by innate immune cells such as natural killer (NK) cells. Thus, it appears that the crucial difference between innate and adaptive immunity is the presence of the naïve state. This important distinction raises an intriguing new hypothesis, that th..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Australian Research Council


Awarded by NHMRC


Funding Acknowledgements

This research was funded by grants from the National Health and Medical Research Council of Australia (Project grant APP1003131 awarded to S.J.T); and an Australian Research Council Discovery Grant (DP170102020 awarded to S.J.T); S.J.T is supported by an NHMRC Principal Research Fellowship; T.J.B is supported by an Australian Postgraduate Award; V.A.V.U is supported by an postgraduate award from the Bonn University-University of Melbourne Graduate program. The A.P.C was funded by NHMRC project grant APP1003131.