Antibody Dynamics for Plasmodium vivax Malaria: A Mathematical Model.
Somya Mehra, James M McCaw, Mark B Flegg, Peter G Taylor, Jennifer A Flegg
Bulletin of Mathematical Biology | Springer (part of Springer Nature) | Published : 2021
Malaria is a mosquito-borne disease that, despite intensive control and mitigation initiatives, continues to pose an enormous public health burden. Plasmodium vivax is one of the principal causes of malaria in humans. Antibodies, which play a fundamental role in the host response to P. vivax, are acquired through exposure to the parasite. Here, we introduce a stochastic, within-host model of antibody responses to P. vivax for an individual in a general transmission setting. We begin by developing an epidemiological framework accounting for P. vivax infections resulting from new mosquito bites (primary infections), as well as the activation of dormant-liver stages known as hypnozoites (relaps..View full abstract
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Awarded by Australian Mathematical Sciences Institute
Awarded by Australian Research Council Discovery Project
Awarded by Australian Research Council DECRA Fellowship
Awarded by Australian Research Council Laureate Fellowship
S. Mehra acknowledges funding from the Australian Mathematical Sciences Institute (AMSI) Vacation Research Scholarships 2018/2019. J.M. McCaw's research is supported by the Australian Research Council (ARC) Discovery Project DP170103076. J.A. Flegg's research is supported by the ARC DECRA Fellowship DE160100227. P.G. Taylor's research is supported by the ARC Laureate Fellowship FL130100039 and the ARC Centre of Excellence for the Mathematical and Statistical Frontiers (ACEMS).