Journal article

Antibody Dynamics for Plasmodium vivax Malaria: A Mathematical Model.

Somya Mehra, James M McCaw, Mark B Flegg, Peter G Taylor, Jennifer A Flegg

Bulletin of Mathematical Biology | Springer (part of Springer Nature) | Published : 2021

Abstract

Malaria is a mosquito-borne disease that, despite intensive control and mitigation initiatives, continues to pose an enormous public health burden. Plasmodium vivax is one of the principal causes of malaria in humans. Antibodies, which play a fundamental role in the host response to P. vivax, are acquired through exposure to the parasite. Here, we introduce a stochastic, within-host model of antibody responses to P. vivax for an individual in a general transmission setting. We begin by developing an epidemiological framework accounting for P. vivax infections resulting from new mosquito bites (primary infections), as well as the activation of dormant-liver stages known as hypnozoites (relaps..

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Grants

Awarded by Australian Mathematical Sciences Institute


Awarded by Australian Research Council Discovery Project


Awarded by Australian Research Council DECRA Fellowship


Awarded by Australian Research Council Laureate Fellowship


Funding Acknowledgements

S. Mehra acknowledges funding from the Australian Mathematical Sciences Institute (AMSI) Vacation Research Scholarships 2018/2019. J.M. McCaw's research is supported by the Australian Research Council (ARC) Discovery Project DP170103076. J.A. Flegg's research is supported by the ARC DECRA Fellowship DE160100227. P.G. Taylor's research is supported by the ARC Laureate Fellowship FL130100039 and the ARC Centre of Excellence for the Mathematical and Statistical Frontiers (ACEMS).