Recording of Electrically Evoked Neural Activity and Bladder Pressure Responses in Awake Rats Chronically Implanted With a Pelvic Nerve Array
Sophie C Payne, Nicole M Wiedmann, Calvin D Eiber, Agnes W Wong, Philipp Senn, Peregrine B Osborne, Janet R Keast, James B Fallon
Frontiers in Neuroscience | FRONTIERS MEDIA SA | Published : 2020
Bioelectronic medical devices are well established and widely used in the treatment of urological dysfunction. Approved targets include the sacral S3 spinal root and posterior tibial nerve, but an alternate target is the group of pelvic splanchnic nerves, as these contain sacral visceral sensory and autonomic motor pathways that coordinate storage and voiding functions of the bladder. Here, we developed a device suitable for long-term use in an awake rat model to study electrical neuromodulation of the pelvic nerve (homolog of the human pelvic splanchnic nerves). In male Sprague-Dawley rats, custom planar four-electrode arrays were implanted over the distal end of the pelvic nerve, close to ..View full abstract
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Awarded by National Institutes of Health, Office of the Director, Stimulating Peripheral Activity to Relieve Conditions (SPARC) Program
Research reported in this publication received funding from GSK Bioelectronics Innovation Challenge (JF and JK). This funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. The study also received funding from the National Institutes of Health, Office of the Director, Stimulating Peripheral Activity to Relieve Conditions (SPARC) Program, Award Number OT2OD023872 (JK, PO, and JF). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.