Mini Review: Central Organization of Airway Afferent Nerve Circuits
Robert Behrens, Alice E McGovern, Michael J Farrell, Aung Aung Kywe Moe, Stuart B Mazzone
NEUROSCIENCE LETTERS | ELSEVIER IRELAND LTD | Published : 2021
Airway afferents monitor the local chemical and physical micro-environments in the airway wall and lungs and send this information centrally to regulate neural circuits involved in setting autonomic tone, evoking reflex and volitional respiratory motor outflows, encoding perceivable sensations and contributing to higher order cognitive processing. In this mini-review we present a current overview of the central wiring of airway afferent circuits in the brainstem and brain, highlighting recent discoveries that augment our understanding of airway sensory processing. We additionally explore how advances in describing the molecular diversity of airway afferents may influence future research effo..View full abstract
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Awarded by National Health & Medical Research Council (NHMRC) of Australia
This research was supported by grants to Dr Mazzone, Dr Farrell and Dr McGovern from the National Health & Medical Research Council (NHMRC) of Australia (APP1042528; APP1121376).