Journal article

The distribution and chemical coding of enteroendocrine cells in Trypanosoma cruzi-infected individuals with chagasic megacolon

Patricia Rocha Martins, Josiane Fakhry, Adriana Jacauna de Oliveira, Thayse Batista Moreira, Linda J Fothergill, Enio Chaves de Oliveira, Debora d'Avila Reis, John B Furness

Histochemistry and Cell Biology | SPRINGER | Published : 2021


Chagas disease is caused by the parasite, Trypanosoma cruzi that causes chronic cardiac and digestive dysfunction. Megacolon, an irreversible dilation of the left colon, is the main feature of the gastrointestinal form of Chagas disease. Patients have severe constipation, a consequence of enteric neuron degeneration associated with chronic inflammation. Dysmotility, infection, neuronal loss and a chronic exacerbated inflammation, all observed in Chagas disease, can affect enteroendocrine cells (EEC) expression, which in turn, could influence the inflammatory process. In this study, we investigated the distribution and chemical coding of EEC in the dilated and non-dilated portion of T. cruzi-..

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University of Melbourne Researchers