Journal article

Outcome and prognosis for canine appendicular osteosarcoma treated with stereotactic body radiation therapy in 123 dogs

Tiffany Wormhoudt Martin, Lynn Griffin, James Custis, Stewart D Ryan, Mary Lafferty, Mary-Keara Boss, Daniel Regan, Sangeeta Rao, Leary Del, Stephen J Withrow, Susan M LaRue

VETERINARY AND COMPARATIVE ONCOLOGY | WILEY | Published : 2021

Abstract

Canine appendicular osteosarcoma is commonly treated with limb amputation; however, limb-sparing options are frequently desired or necessary for a subset of patients. We evaluated 123 patients and 130 sites treated with stereotactic body radiation therapy (SBRT). Eighty-two out of 98 dogs (84%) had maximum lameness improvement at a median of 3 weeks for a median of 6 months duration. Histopathologic evaluation of available samples from amputation or necropsy revealed >80% tumor necrosis in 50% of limbs consistent with local disease control. Of evaluable patients, 41% fractured and 21% pursued an amputation after treatment. Fine needle aspirate (n = 52) and needle core biopsy (n = 28) did not..

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University of Melbourne Researchers