Journal article

Transcriptomic profiles of Plasmodium falciparum and Plasmodium vivax-infected individuals in Indonesia

Katalina Bobowik, Din Syafruddin, Chelzie Crenna Darusallam, Herawati Sudoyo, Christine Wells, Irene Gallego Romero

Cold Spring Harbor Laboratory | Published : 2021

Abstract

Malaria is one of the leading causes of illness and death globally. The vast majority of transcriptomic studies of the impact of malaria on human hosts have been conducted on populations of African ancestry suffering from Plasmodium falciparum infection, making it unclear whether biological responses observed in these studies can be generalised to other populations. Here, we perform differential expression analysis between healthy controls and malaria-infected patients within Indonesia, a country of over 260 million people which has substantial morbidity due to endemic malaria. We find that in samples infected with P. falciparum and P. vivax , there is an upregulation of genes involved in in..

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