Journal article

Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

Eva Velthorst, Josephine Mollon, Robin M Murray, Lieuwe de Haan, Inez Myin Germeys, David C Glahn, Celso Arango, Els van der Ven, Marta Di Forti, Miguel Bernardo, Sinan Guloksuz, Philippe Delespaul, Gisela Mezquida, Silvia Amoretti, Julio Bobes, Pilar A Saiz, Maria Paz Garcia-Portilla, Jose Luis Santos, Estela Jimenez-Lopez, Julio Sanjuan Show all

Molecular Psychiatry | SPRINGERNATURE | Published : 2021


Important questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. The age-associated profile of familial impairments also remains unclear, as well as the effect of factors, such as symptoms, functioning, and medication. Using cross-sectional data from the EU-GEI and GROUP studies, comprising 8455 participants aged 18 to 65, we examined cognitive functioning across adulthood in patients with psychotic disorders (n = 2883), and their unaffected siblings (n = 2271), compared to controls (n = 3301). An abbreviated WAIS-III measured verbal knowledge, working memory, visuospatial processing, processing speed, and IQ. Patients showed me..

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Awarded by European Community's Seventh Framework Programme

Awarded by NHMRC

Awarded by Australian National Health & Medical Research Council (NHMRC-EU)

Awarded by French Ministry grant

Awarded by Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III

Awarded by Madrid Regional Government

Awarded by FAPESP-Brazil

Awarded by Medical Research Council Fellowship

Funding Acknowledgements

The European Community's Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (EUGEI). The Geestkracht programme of the Dutch Health Research Council (Zon-Mw)(GROUP). Dr. Velthorst is supported by The Seaver Foundation. Dr. Pantelis was supported by a NHMRC Senior Principal Research Fellowship (ID: 1105825), a NHMRC Program Grant (ID: 1150083). The Melbourne arm of the study was supported by a grant from the Australian National Health & Medical Research Council (NHMRC-EU grant ID: 567215). The French cohort was supported by the French Ministry grant (PHRC ICAAR -AOM07-118). The Spanish sample was supported by the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/024), Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), Fundacion Familia Alonso and Fundacion Alicia Koplowitz. The Brazilian sample was supported by FAPESP-Brazil (grant 2012/05178-0). Additional support was provided by a Medical Research Council Fellowship to Dr. Kempton (grant MR/J008915/1). Dr. Kirkbride was supported by the National Institute for Health Research University College London Hospital Biomedical Research Centre. Dr. Nelson was supported by an NHMRC Senior Research Fellowship (1137687). We would like to thank the EU-GEI WP2 Group not mentioned in main author list: Kathryn Hubbard, Stephanie Beards, Simona A. Stilo, Pedro Cuadrado, Jose Juan Rodriguez Solano, David Fraguas, Alvaro Andreu-Bernabeu, Gonzalo Lopez, Bibiana Cabrera, Juan Nacher, Javier Costas, Mario Matteis [8], Marta Rapado-Castro, Emiliano Gonzalez, Covadonga M. Diaz-Caneja [8], Emilio Sanchez, Manuel Duran-Cutilla, Nathalie Franke, Fabian Termorshuizen, Daniella van Dam, Elles Messchaart, Marion Leboyer [4], Franck Schu<spacing diaeresis>rhoff, Stephane Jamain, Gregoire Baudin, Aziz Ferchiou, Baptiste Pignon, Jean-Romain Richard, Thomas Charpeaud, Anne-Marie Tronche, Flora Frijda, Giovanna Marrazzo, Crocettarachele Sartorio, Fabio Seminerio, Camila Marcelino Loureiro, Rosana Shuhama, Mirella Ruggeri, Chiara Bonetto, Doriana Cristofalo, Domenico Berardi, Marco Seri, Elena Bonora, Anastasios Nougus, Giuseppe D'Andrea, Laura Ferraro, Giada Tripoli, Ulrich Reininghaus, Enrique Garcia Bernardo, Laura Roldan, Esther Lorente-Rovira, Ma Soledad Olmeda, Daniele La Barbera, Cristina M. Del-Ben, Lucia Sideli. Study funders contributed to the salaries of the research workers employed, but did not participate in the study design, data analyses, data interpretation, or writing of the manuscript. All authors had full access to the study data and had final responsibility for the decision to submit for publication.