High-Frequency Oscillations in Epilepsy: What Have We Learned and What Needs to be Addressed.
Zhuying Chen, Matias I Maturana, Anthony N Burkitt, Mark J Cook, David B Grayden
Neurology | Published : 2021
For the past 2 decades, high-frequency oscillations (HFOs) have been enthusiastically studied by the epilepsy community. Emerging evidence shows that HFOs harbor great promise to delineate epileptogenic brain areas and possibly predict the likelihood of seizures. Investigations into HFOs in clinical epilepsy have advanced from small retrospective studies relying on visual identification and correlation analysis to larger prospective assessments using automatic detection and prediction strategies. Although most studies have yielded promising results, some have revealed significant obstacles to clinical application of HFOs, thus raising debate about the reliability and practicality of HFOs as ..View full abstract