Molecular subtypes of gastric cancer show systematic differences in response to PI3K inhibitors and fluorouracil.
Zengdeng Lei, Nian Tao Deng, Hermioni Zouridis, Iain Beehaut Tan, Chia Huev Ooi, Tatiana Ivanova, Shenli Zhang, Minghui Lee, Jeanie Wu, Anna Ngo, Sravanthy Manesh, Alex Boussioutas, Tean Teh Bin, Liang Kee Goh, Horst Flotow, Tan Patrick, Steven G Rozen
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2013
Abstract Background & Aims: Gastric cancer is the second leading cause of cancer death worldwide, killing >730,000 people every year. Almost all gastric cancers are adenocarcinomas, which exhibit considerable heterogeneity between patients. We sought to identify subtypes of gastric adenocarcinomas that have particular biological properties and responses to cytotoxic drugs. Methods: Robust unsupervised clustering of 248 gastric tumors based on global gene expression revealed three major subtypes. We developed a classifier, GC-Class ("Gastric Cancer Classifier") for the three subtypes and validated it in a second set of 70 tumors. We then determined the distinct genomic and e..View full abstract