Conference Proceedings
Abstract 2167: Unbiased genomic approaches identify 2 major subclasses of Gastric Cancer with prognostic and predictive value superior to Lauren's and also reveals subtype-specific treatment opportunities
Iain B Tan, Julian Lee, ChiaHuey Ooi, MingHui Lee, Alex Boussioutas, Manuel S Tallez, Joanne Ngeow, KiatHon Lim, Jimmy So, SuPin Choo, WaiKeong Wong, Patrick Tan
Cancer Research | American Association for Cancer Research (AACR) | Published : 2010
Abstract
Abstract Introduction: The Lauren's classification of gastric cancer (GC) is widely used with 2 subtypes, intestinal and diffuses having distinct histo-pathological and epidemiological characteristics. Beyond diagnosis, Lauren's classes have limited prognostic and no predictive value. Methods: We performed gene expression profiling on 37 GC cell lines (GCCL) and 2 independent cohorts of 200 (SG) and 68 (AU) primary GC tumors. We used integrative molecular profiling to discover and characterise molecular subtypes of GC. Results: Unsupervised hierarchal clustering in GCCLs identified 2 distinct major molecular subtypes termed “G1”and “G2”. Linear mo..
View full abstract