Journal article

Abstract WMP18: Regional Comparison of Functional Connectivity Between “Salvaged” Peri-Infarct and Infarcted Tissue

Felix C Ng, Vijay Venkatraman, Nawaf Yassi, Mark Parsons, Andrew Bivard, Gagan Sharma, Patricia Desmond, Stephen Davis, Bruce C Campbell

Stroke | Ovid Technologies (Wolters Kluwer Health) | Published : 2019

Abstract

Introduction: Even when accounting for lesion topography, radiological Final Infarct Volume (FIV) after acute ischemic stroke (AIS) correlates only moderately with clinical outcome. Pathology in normal-appearing “salvaged” peri-infarct tissue and partial preservation within radiologically infarcted tissue may contribute to the variance between FIV and clinical outcome. We sought to evaluate the degree of neuronal dysfunction within infarcted, peri-infarct and remote regions on follow-up MRI after AIS. Methods: In a single-centre prospective study, twenty AIS patients underwent resting state functional MRI at 1 month. Asymmetry compare..

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