79.

Abstract

Current clinical application of thrombolysis in stroke is limited by the 4.5hour time window and not applicable to patients with wake up stroke (WUS). Patient selection using advanced penumbral imaging criteria may allow extension of the therapeutic window. The EXtending the time for Thombolysis in Emergency Neurological Deficits (EXTEND) trial aims to test the hypothesis that perfusion-core mismatch can be used to select patients with favourable response to thrombolysis beyond conventional time windows. EXTEND is an investigator initiated, randomised, double-blind, placebo controlled phase 3 trial of intravenous alteplase versus placebo in patients with ischemic stroke 4.5–9hours from strok..