Journal article
MRI lesion profiles in sporadic Creutzfeldt–Jakob disease
B Meissner, K Kallenberg, P Sanchez-Juan, D Collie, DM Summers, S Almonti, SJ Collins, P Smith, P Cras, GH Jansen, JP Brandel, MB Coulthart, H Roberts, B Van Everbroeck, D Galanaud, V Mellina, RG Will, I Zerr
Neurology | Published : 2009
Abstract
ABSTRACT Background: With respect to sporadic Creutzfeldt–Jakob disease (sCJD), six molecular subtypes (MM1, MM2, MV1, MV2, VV1, and VV2) have been described, which vary with respect to age at disease onset, disease duration, early symptoms, and neuropathology. MRI signal alterations were reported to correlate with distinct Creutzfeldt–Jakob disease (CJD) subtypes. This multicenter, international study aimed to describe the brain MRI findings associated with each of the sCJD molecular subtypes. Methods: Pathologically confirmed sCJD cases with codon 129 genotype (MM, MV, and VV), PrPSc type, and fluid-attenuated inversion recovery (FLAIR) or diffusion-weighted imaging (DWI) were collected in..
View full abstract